A schedule can make or break a season. Ask any coach.

Purdue's 2021 slate is filled with challenges and opportunities. This series is a breakdown of what's ahead for the Boilermakers this fall.

• Toughest non-conference game: at Notre Dame, Sept. 18

• Toughest conference game: at Ohio State, Nov. 13

• Who they don't play: Penn State, Michigan, Rutgers, Maryland

• Easiest game: at UConn, Sept. 11

• Toughest stretch: Nov. 13-27, at Ohio State; at Northwestern (Wrigley Field); vs. Indiana

• Best chance to be upset

• Best chance to pull an upset

Next up: Best chance to be upset